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Composition

Bicotrim Tablets:

Bicotrim 120
Sulphametoxazole 100mg+ Trimethoprim 20mg

Bicotrim 480
Sulphametoxazole 400mg+ Trimethoprim 80mg

Bicotrim 960
Sulphametoxazole 800mg+ Trimethoprim 160mg

Bicotrim Suspension:
Each 5 ml contains Sulphametoxazole 200mg+ Trimethoprim 40mg

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Indications
- Urinary tract infections
- Acute otitis media in paediatric patients
- Acute exacerbations of chronic bronchitis in adults
- Traveller’s Diarrhoea in adults
- Pneumocystis carinii
pneumonia

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Dosage and Administration
Bicotrim should be taken with fluid, preferably after a meal. Adequate fluids should be taken when on Bicotrim. The patient should notify the physician of skin rash, sore throat, fever or unusual bruising or bleeding.

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Adults and children (above 12 years)
Contraindicated in pediatric patients less than 2 months of age.
Urinary Tract Infections and Shigellosis in adults and pediatric patients and acute otitis media in pediatric patients.

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Adults
The usual adult dosage in the treatment of urinary tract infections is 1 Bicotrim tablet, or 4 teaspoonful Bicotrim suspension every 12 hours for 10 to 14 days. An identical dosage is used for 5 days in the treatment of Shigellosis.

Acute Exacerbation of Chronic bronchitis
1 Bicotrim tablets, or 4 teaspoonful of Bicotrim suspension every 12 hours for 14 days.

Travelers Diarrhoea
1 Bicotrim tablet, or 4 teaspoonful of Bicotrim suspension every 12 hours for 5 days.

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Pediatric patients
The recommended dose for pediatric patients with urinary tract infections and acute otitis media is 8 mg/kg trimethoprim and 40 mg/kg sulfamethoxazole per 24 hours, given in two divided doses every 2 hours for 10 days. An identical daily dosage is used for 5 days in the treatment of Shigellosis.

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Pneumocyst carinii pneumonia: Treatment

Adults and Paediatric Patients
The recommended dosage for treatment of patients with documented Pneumocystis carinii pneumonia is 15 to 20 mg/kg trimethoprim and 75 to 100 mg/kg sulfamethoxazole per 24 hours given in equally divided doses every 6 hours for 14 to 21 days.

Prophylaxis

Adults
1 Bicotrim tablet daily.

Paediatric patients
The recommended dose is 150 mg/m 2 /day trimethoprim with 750 mg/m 2 / day sulfamethoxazole given orally in equally divided doses twice a day, on 3 consecutive days per week.

The total daily dose should not exceed 320 mg trimethoprim and 1,600 mg sulfamethoxazole.

Contraindications
Marked liver parenchymal damage, blood dyscrasias, severe renal insufficiency and glucose 6-phosphate dehydrogenase deficiency, known hypersensitivity to sulphonamides and/or trimethoprim. Treatment must be discontinued on the appearance of a skin rash, or if any element of the blood count is reduced.

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Presentation

Bicotrim 120 Blister of 10 tablets

Bicotrim 480
Blister of 10 tablets

Bicotrim 960
Blister of 10 tablets

Bicotrim Suspension
Bottle of 100ml



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