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ACIHERPIN 5% CREAM 5 g
ACIHERPIN TABLETS 200 mg
ACIHERPIN INJECTION 250 mg
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ACIHERPIN 5% CREAM 5 g
Composition
Each g of Cream contains Acyclovir BP 5%w/w
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Indications
Cold sores (herpes simplex virus)
Genital herpes
Herpes simplex infections of the skin, eg. herpes, cold
sores
Dosage and Administration
The preparation is applied topically to the skin.
Acyclovir skin cream should be applied five times daily at
approximately four hourly intervals, omitting the nighttime
application.
Contraindications
Topical acyclovir is contraindicated in patients who develop
hypersensitivity or chemical intolerance to the drug or
other ingredients in the formulation.
There are no adequate and controlled studies to date using
acyclovir in pregnant women, and the drug should be used
during pregnancy only when the potential benefits justify
the possible risks to the fetus.
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Presentation
An aluminium tube of 5 gm packed in a carton along with
insert literature.
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ACIHERPIN TABLETS 200 mg
Composition
Each Uncoated Tablet Contains Acyclovir BP 200 mg
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Indications
1. Treatment of herpes simplex keratitis
2. Treatment of herpes simplex infections of skin and mucous
secretion
3. Treatment of serve and/or generalised herpes simplex
infections in immunocompromised and normally immune
individuals
4. Prophylaxis of genital herpes simplex in the
immunocompromised.
5. Suppression of genital herpes simplex in immunocompetent
individuals with very frequent recurrences.
6. Treatment of varicella-zoster infections in
immunocompromised and normally immune individuals.
Dosage and Administration
Dosage for treatment of Herpes simplex in adults: For
treatment of Herpes simplex infections one 200mg Aciclovir
tablet should be taken five times daily at approximately
four-hourly intervals.
Treatment should continue for 5 days, but in severe initial
infections may have to be extended.
Dosing should begin as early as possible after the start of
an infection. For recurrent episodes this should preferably
be during the prodromal period or when lesions first appear.
Dosage for Suppression of Herpes simplex in Adults:
For suppression of Herpes simplex infections in
immune-competent patients, one 200mg Aciclovir tablet should
be taken four times daily at approximately six-hourly
intervals.
Dosage for Prophylaxis of Herpes simplex in Adults:
For prophylaxis of Herpes simplex infections in
immunocompromised patients, 200mg aciclovir should be taken
four times daily at approximately six-hourly intervals.
Dosage in Renal Impairment: for patients with severe
renal impairment (creatinine clearance less than 10
ml/minute) an adjustment of dosage to 200mg twice daily at
approximately twelve-hourly intervals is recommended.
Contraindications
Acyclovir tablets are contraindicated in patients known to
be hypersensitive to acyclovir.
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Presentation
Two blister packs, each containing ten tablets, are packed
in a carton along with insert literature.
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ACIHERPIN INJECTION 250 mg
Composition
Each Vial contains:
Sterile Acyclovir Sodium Equivalent to Acyclovir BP 250 mg
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Indications
Herpes Simplex Infections in Immunocompromised Patients
Initial episodes of genital Herpes:
Herpes Simplex Encephalitis
Neonatal Herpes Simplex Virus Infection:
Varicella-Zoster Infections in Immunocompromised Patients
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Dosage and Administration
Dosage in Herpes simplex infections:
Mucosal and Cutaneous Herpes simplex (HSV-1 and HSV-2)
Infections in Immunocompromised Patients:
Adults and Adolescents: 5 mg/kg infused at a contant
rate over 1 hour, every 8 hours for 7 days.
Pediatrics (Under 12 years of age): 10 mg/kg infused at
a constant rate over 1 hour, every 8 hours for 7days.
Severe Initial clinical episodes of herpes genitalis:
Adults and Adolescents (12 years of age and older):
5 mg/kg infused at a constant rate over 1 hour, every 8
hours for 5 days.
Herpes Simplex Encephalitis:
Adults and adolescents (12 years of age and older): 10
mg/kg infused at a constant rate over 1 hour, every 8 hours
for 10 days.
Pediatrics (3 months to 12 years of age): 20
mg/kg infused at a constant rate over 1 hour, every 8 hours
for 10 days.
Neonatal Herpes Simplex Virus Infections (Birth to 2
months): 10 mg/kg infused at a constant rate over 1
hour, every 8 hours for 10 days. In neonatal herpes simplex
infections, doses of 15 mg/kg or 20 mg/kg have been used;
the safety and efficacy of these doses are not known.
Varicella Zoster Infections: Zoster in Immunocompromised
patients:
Adults and Adolescents (12 years of age and older): 10
mg/kg infused at a constant rate over 1 hour, every 8 hours
for 7 days.
Pediatrics (Under 12 years of age): 20 mg/kg infused
at a constant rate over 1 hour, every 8 hours for 7 days.
Obese patients: Obese patients should be dosed at the
recommended adult dose using Ideal Body Weight.
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Contraindications
ACIHERPIN Injection is contraindicated for patients who
develop hypersensitivity to acyclovir or valacyclovir.
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Presentation
One vial is packed in a printed primary carton along with
insert literature.
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